en تخصصي Special پژوهشي Original Article <strong>Background and Objectives:</strong> Prostate cancer is the third most important cause of cancer deaths and one of the most common cancers in the world. Given the limited knowledge on environmental sounds and their effects, the important role of sounds is neglected in every culture across the world. The aim of this study was to investigate the impact of <em>Quran</em> recitation on prostate cancer cell line (PC-3) and compare it with the effects of cisplatin.<br> <strong>Methods:</strong> The effects of cisplatin and Quran recitation on the viability and migration capacity of PC-3 cells were investigated by evaluating <em>BCL2L12</em>. In addition, mRNAs were assessed by real-time polymerase chain reaction (RT-PCR). Gene expressions of <em>BCL2L12</em> and <em>TBP</em> were investigated as target and internal control genes, respectively.<br> <strong>Results:</strong> The results of the in vitro assay showed a considerable inhibitory effect of <em>Quran</em> recitation on the proliferation and migration of PC-3 cells. Furthermore, the significant inhibitory effects of cisplatin on the proliferation and migration of PC-3 cells exposed to <em>Quran</em> recitation was more than that of the PC-3 cells only treated with cisplatin. Results of quantitative real time PCR demonstrated that the gene expression of <em>BCL2L12</em> was significantly down regulated in PC-3 cells treated by cisplatin and those exposed to both cisplatin and <em>Quran</em> recitation.<br> <strong>Conclusion: </strong>This was the first report about the direct effects of <em>Quran</em> recitation on non-auditory cells in culture. The results of this study suggested that <em>Quran</em> recitation could alter cell proliferation via the down regulation of <em>BCL2L12</em> and migration of PC-3 cells.<br> &nbsp; Quran Recitation, Prostate Cancer, Apoptosis, Cell Viability, BCL2L12. 46 52 http://jhsme.muq.ac.ir/browse.php?a_code=A-10-214-1&slc_lang=en&sid=1 Ali Mehrafsar mehrafsar3@gmail.com 0000-0002-9613-4243 No Department of Biology, Zarghan Branch, Islamic Azad University, Zarghan, Iran Mohammad Javad Mokhtari mj.mokhtari@gmail.com 0000-0001-5066-9632 Yes Department of Biology, Zarghan Branch, Islamic Azad University, Zarghan, Iran